Nandan S. Gokhale

Comprehensive Atomic-Scale 3D Viral-Host Protein Interactomes Enable Dissection of Key Mechanisms and Evolutionary Processes Underlying Viral Pathogenesis

The paper predicts 3D structures of viral-host protein interactions and identifies evolutionary patterns and functional mechanisms underlying viral pathogenesis.

CELF2 suppresses endogenous RNA ligands that activate RIG-I-mediated interferon induction

FTO suppresses STAT3 activation and modulates proinflammatory interferon-stimulated gene expression

The paper shows FTO suppresses proinflammatory ISG expression by inhibiting STAT3 activation during the type I IFN response.

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

The paper uses direct RNA long-read sequencing to show m6A modifications on adenovirus RNA are necessary for efficient splicing.

Limits in the detection of m6A changes using MeRIP/m6A-seq

This study evaluates the reproducibility of m6A peak detection and changes using MeRIP-seq and finds limited consistency across studies.

Altered m6A modification of specific cellular transcripts affects Flaviviridae infection

This study shows that Flaviviridae viruses alter m6A modification of specific host transcripts, affecting viral infection through changes in translation and splicing.