Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity
Christian B. Lessard, Diego Rubio-Rubio, Samantha G Tolton…·Jose Francisco Abisambra
This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.