Author

Mary R. Guest

Frederick National Laboratory for Cancer ResearchORCID 0000-0003-0688-3214Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Raj ChariiD· 2 shared Anjali Nandal· 1 shared Anthony M. CianconeiD· 1 shared Arati RaziuddiniD· 1 shared Austin T.K. HokeiD· 1 shared Charalampos S. FloudasiD· 1 shared Christine N. MilleriD· 1 shared Elijah F. EdmondsoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Raj ChariORCID

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2 papers

Recent·Most cited

Cell BiologyMolecular CellPeer-reviewedJul 21, 2026

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy

Kitaik Lee, Hitendra Negi, Xiang Chen…·Francis J. O’Reilly

The paper uses PhIX-MS and cryo-EM to map transient interactions at proteasomes, revealing structural details of proteins like TXNL1 and PSMD5.

4 citationstop 3%

cryo-EMproteomics

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Cancer BiologybioRxivPreprintMay 19, 2025

In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis

Kenny Vu, Sreenivasulu Gunti, Ramya Viswanathan…·Nyall R. London

This study identifies NF1/RASA1/TP53 co-mutations and MEK signaling as key drivers of sinonasal tumorigenesis through in vivo CRISPR screening and drug response testing.

DOI 10.1101/2025.05.19.654661

mousegenetic perturbation / CRISPR

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