Author

Kitaik Lee

National Cancer InstituteORCID 0000-0002-7761-5586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

Francis J. O’ReillyiD· 2 shared Andreas BolandiD· 1 shared Andrew HoweiD· 1 shared Anthony M. CianconeiD· 1 shared Chloe M. GhentiD· 1 shared Daniela Portugal-CalistoiD· 1 shared David O. MorganiD· 1 shared Dorothea FiedleriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Francis J. O’ReillyORCID

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3 papers

Recent·Most cited

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy

Kitaik Lee, Hitendra Negi, Xiang Chen, Katerina Atallah-Yunes, Sunny Truslow, Rithik E. Castelino, Mary R. Guest, Anthony M. Ciancone, Xiuxiu Lu, Sergey G. Tarasov, Raj Chari, Kylie J. Walters, Francis J. O’Reilly

The paper uses PhIX-MS and cryo-EM to map transient interactions at proteasomes, revealing structural details of proteins like TXNL1 and PSMD5.

Molecular Cell · Jul 21, 2026Peer-reviewedCell Biology

Substrate recognition by human separase

Jun Yu, Sophia Schmidt, Margherita M. Botto, Kitaik Lee, Chloe M. Ghent, Jonah M. Goodfried, Andrew Howe, Francis J. O’Reilly, David O. Morgan, Andreas Boland

This study determines cryoEM structures of human separase in apo and substrate-bound forms, revealing substrate recognition mechanisms and cleavage regulation.

Science Advances · Nov 12, 2025Peer-reviewedBiochemistry

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis.

Pierre Raia, Kitaik Lee, Simon M. Bartsch, Felix Rico-Reséndiz, Daniela Portugal-Calisto, Oscar Vadas, Vikram Govind Panse, Dorothea Fiedler, Michael Hothorn

This study identifies a GAF signaling domain that regulates PPIP5K phosphatase activity in phosphate homeostasis through structural and functional analyses.

Nature Communications · Feb 18, 2025Peer-reviewedBiochemistry