Jeffri S. Retamal

TRPV4 Promotes Histamine Receptor Signaling in Lymphatic Endothelial Cells

This study shows TRPV4 mediates histamine receptor signaling in lymphatic endothelial cells, enhancing Ca2+ signaling and NFATc1 translocation while cytokine release occurs through distinct mechanisms.

Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch

This study shows MrGPRX1 signals from endosomes to sensitize TRPV1, enhancing itch signaling, and identifies pathways involved in this process.

Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

Characterization and targeting of the endosomal signaling of the gastrin releasing peptide receptor in pruritus.

This study investigates GRPR endosomal signaling in pruritus and shows that endosomal targeting of GRPR antagonists is more effective in blocking itch sensation.