Francesco Petrelli

This study identifies Ackr3 as a regulator of astrocyte-mediated synaptic removal in disease, showing its role in synapse engulfment and its upregulation in Alzheimer's disease.

This study identifies varicose projection astrocytes as a reactive phenotype associated with neuropathology, showing their presence in humans, mice, and tigers and their induction by inflammation.

This study identifies PEA116, an astrocyte-derived peptide that enhances adult hippocampal neurogenesis and stress resilience by promoting aNSC proliferation through ERK2 phosphorylation.

This study identifies Fer2 as a conserved transcription factor that maintains mitochondrial integrity in midbrain dopaminergic neurons, protecting against neurodegeneration in Parkinson's disease.

This study shows that reduced VMAT2 in astrocytes of the mouse medial prefrontal cortex leads to excessive grooming and anxiety-like behavior, with synaptic changes in the dorsal striatum.