Laura Civiero

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

This study shows that LRRK2 regulates synaptic function by modulating actin cytoskeletal dynamics through BDNF signaling in neurons.

Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes

This study identifies Ackr3 as a regulator of astrocyte-mediated synaptic removal in disease, showing its role in synapse engulfment and its upregulation in Alzheimer's disease.

Parkinson disease-associated protein DJ-1 regulates the autophagic-lysosomal pathway through ROS-dependent modulation of the AMPK/mTORC1 axis.

This study shows that DJ-1 deficiency impairs autophagosome-lysosome fusion and lysosomal degradation, leading to autophagic substrate accumulation through ROS-dependent modulation of the AMPK/mTORC1 axis in Parkinson's disease.

LRRK2 G2019S disrupts GABAergic signaling and shifts excitatory/inhibitory balance in the striatum

This paper shows that the LRRK2 G2019S mutation reduces GABA-evoked currents and disrupts the excitatory/inhibitory balance in the striatum.

SPROUTS_DB: an implemented database of contaminants for extracellular vesicle proteomics studies

SPROUTS_DB catalogs serum-derived contaminants in extracellular vesicle proteomics to improve data reliability by distinguishing contaminants from true proteins.

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner

This study identifies PAK6 as a modifier of LRRK2 mutations, showing it rescues ciliogenesis defects in G2019S but not R1441C mutations.

PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation.

This study identifies PAK6 as a positive regulator of neuronal autophagy through TFEB nuclear translocation, with implications for neurodegenerative disease treatment.

Prospective role of PAK6 and 14-3-3 gamma as biomarkers for Parkinson's disease

This study quantifies PAK6 and 14-3-3 gamma in plasma to assess their potential as biomarkers for diagnosing sporadic and LRRK2-linked Parkinson's disease.

Investigation of microglial diversity in a mouse model of Parkinson's disease pathology

This study investigates the role of CLEC7A-positive microglia and dark microglia in a mouse model of Parkinson's disease with the LRRK2 G2019S mutation, revealing their association with cellular stress and pathology.

The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease

The paper investigates the relationship between LRRK2 and GCase activities in Parkinson's disease models and biospecimens, finding a positive correlation.

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease

This study shows that the LRRK2 G2019S mutation impairs EAAT2 trafficking, leading to reduced glutamate clearance and potential neurodegeneration in Parkinson's disease.