Paula Ramos‐Gonzalez

This study identifies Ackr3 as a regulator of astrocyte-mediated synaptic removal in disease, showing its role in synapse engulfment and its upregulation in Alzheimer's disease.

This paper introduces neuroimmune assembloids, brain organoids with functional microglia-like cells, to study neuroimmune interactions in age-related neurodegenerative diseases.

This study identifies varicose projection astrocytes as a reactive phenotype associated with neuropathology, showing their presence in humans, mice, and tigers and their induction by inflammation.

The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.