Fabio Cavaliere

Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes

This study identifies Ackr3 as a regulator of astrocyte-mediated synaptic removal in disease, showing its role in synapse engulfment and its upregulation in Alzheimer's disease.

An Integrated Neuroimmune Assembloid Model to Advance Neurodegenerative Disease Studies

This paper introduces neuroimmune assembloids, brain organoids with functional microglia-like cells, to study neuroimmune interactions in age-related neurodegenerative diseases.

Phenotypic Signatures of CTNNB1 Syndrome: Longitudinal Neuropsychological Outcomes and Three-Dimensional Facial Morphology

This study provides longitudinal cognitive and facial morphology data for CTNNB1 syndrome, showing stable global functioning and significant facial shape associations with behavioral issues.

Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia

The paper identifies Thbs4-positive astrocytes from the SVZ that modulate the extracellular matrix at the glial scar after brain ischemia by synthesizing and degrading hyaluronan.

Varicose-projection astrocytes: a reactive phenotype associated with neuropathology

This study identifies varicose projection astrocytes as a reactive phenotype associated with neuropathology, showing their presence in humans, mice, and tigers and their induction by inflammation.

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism.

The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.