Tomáš Bárta

This paper develops a cumate-inducible model to study MYC-driven neuroblastoma and identifies mitoribosomal synthetic lethality as a therapeutic target in MYC(N)-amplified tumors.

This study shows that rhythmic light flicker improves photoreceptor maturation in human retinal organoids by enhancing structural development, transcriptional transition, and functional connectivity.

This study shows that the PRPF8-Y2334N variant causes photoreceptor defects in human neural retina cells without affecting the retinal pigment epithelium.

This study uses human retinal organoids to investigate hyperglycaemia's effects on retinal development, finding disruptions in photoreceptor maturation and glial activation.

Daily light exposure improves photoreceptor maturation in retinal organoids without causing cell death.

This study identifies PRICKLE3's role in stabilizing WNT/PCP complexes by inhibiting RNF43-mediated ubiquitination of VANGL1/2.

LuminoCell is an affordable, open-source luminometer platform for real-time monitoring of in-cell luciferase activity in various biological assays.

This study shows that the miR-183/96/182 cluster regulates PAX6 expression and retinal morphogenesis in human retinal organoids.