NeuroscienceNature NeurosciencePeer-reviewed
Modulating D1 rather than D2 receptor-expressing spiny-projection neurons corresponds to optimal antipsychotic effect
Seongsik Yun, Ben Yang, Justin D. Anair…·Jones G. Parker
The paper investigates the neural mechanisms of antipsychotic drugs by comparing their effects on D1- and D2-receptor-expressing spiny-projection neurons in mice, finding that modulating D1-SPNs correlates with therapeutic efficacy.
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