Author

Karen Perez de Arce

Broad InstituteORCID 0000-0003-0750-0588Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Eike‐Christian WamhoffiD· 2 shared Eric DanielsoniD· 2 shared Jeffrey R. Cottrell· 2 shared Mark BatheiD· 2 shared Morgan ShengiD· 2 shared Abasi Ene–ObongiD· 1 shared Adam Skepner· 1 shared Alex Guletsky· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Eike‐Christian WamhoffORCID

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4 papers

Recent·Most cited

Pharmacology & ToxicologyACS Chemical NeurosciencePeer-reviewedOct 29, 2026

Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290

Christopher Greaves, William E. Martenis, Shawn Dwayne Nelson…·Sean P. Moran

This study discovers BRD3290, a GluA3-preferring AMPA receptor PAM, but finds it does not improve cognitive function in mice despite target engagement.

DOI 10.1021/acschemneuro.6c00573

mouseexperimental assay

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GenomicsbioRxivPreprintDec 9, 2022

A survey of proteomic variation across two ethnic groups in Nigeria and its relationship to obesity risk

Arjun Biddanda, Karen Perez de Arce, Golibe Eze-Echesi…·Peter Fekkes

This study examines proteomic variation between two Nigerian ethnic groups and identifies novel cis-pQTL associated with BMI.

DOI 10.1101/2022.12.09.519773

humanproteomics

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NeurosciencebioRxivPreprintJul 11, 2022

Perturbations of a causal synaptic molecular network in autism and schizophrenia revealed with multiplexed imaging

Reuven Falkovich, Eric Danielson, Karen Perez de Arce…·Mark Bathe

The paper uses PRISM to analyze how knocking down 16 autism and schizophrenia genes affects synaptic protein distributions and constructs a causal network model.

DOI 10.1101/2022.07.11.499330

imagingexperimental assay

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NeuroscienceeNeuroPeer-reviewedDec 21, 2020

Molecular diversity of glutamatergic and GABAergic synapses from multiplexed fluorescence imaging

Eric Danielson, Karen Perez de Arce, Beth A. Cimini…·Mark Bathe

The paper uses multiplexed fluorescence imaging and machine learning to identify synaptic subtypes and examine their changes under activity suppression.

18 citations

imagingmachine learning (classical)

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