Author

Ching-Lin Hsieh

The University of Texas at Austin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

Adelaide S. FulleriD· 1 shared Ajit R. RamamohaniD· 1 shared Alan WangiD· 1 shared Alison G. LeeiD· 1 shared Ashley L. MarcinkiewicziD· 1 shared Chelsea M. CrooksiD· 1 shared Dagnija TupiņaiD· 1 shared Dong Liang YuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Adelaide S. FullerORCID

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Author profile →

2 papers

Recent·Most cited

Mechanistic insights into structure-based design of a Lyme disease subunit vaccine

Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz, Alan Wang, Yilin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupiņa, Ināra Akopjana, María Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen‐Hsiang Chen, Yi‐Pin Lin

This study demonstrates that structure-based mutagenesis of CspZ-YA improves antigen stability and immunogenicity, supporting its use in Lyme disease vaccine design.

Nature Communications · Apr 6, 2025Peer-reviewedImmunology

Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation

Madeline R. Sponholtz, Patrick O. Byrne, Alison G. Lee, Ajit R. Ramamohan, Jory A. Goldsmith, Ryan S. McCool, Ling Zhou, Nicole V. Johnson, Ching-Lin Hsieh, Megan Connors, Krithika P. Karthigeyan, Chelsea M. Crooks, Adelaide S. Fuller, John D. Campbell, Sallie R. Permar, , Jason S. McLellan

This paper describes the stabilization of HCMV gB in a prefusion-like conformation using structure-based design and shows similar neutralizing antibody titers against postfusion and prefusion forms.

Proceedings of the National Academy of Sciences · Sep 4, 2024Peer-reviewedMolecular Biology