Ling Zhu

This study investigates the role of alanine transaminase (ALT) in human neural retina metabolism, showing its involvement in carbon/nitrogen flux and redox balance, with potential therapeutic implications for retinal diseases.

The paper identifies differences in stress response and function between macular and peripheral Muller cells, linking these differences to vulnerability to degenerative diseases.

The paper identifies metabolic differences between mouse and human retinas, cones vs. rods, macula vs. periphery, and retina vs. RPE, highlighting distinct metabolic pathways and nutrient exchange.

The paper generates a human neural retina transcriptome atlas using single-cell RNA sequencing, identifying 18 cell types and revealing a novel role for MALAT1 in rod degeneration.