Michael P. Snyder

GATTACA bins metagenomic contigs into species-specific clusters using compact k-mer indexing and MinHash, achieving accuracy comparable to existing methods but with significant speed improvements.

This study identifies NF90/ILF3 as a transcription factor that promotes proliferation over differentiation in K562 cells by hierarchically regulating key transcription factors.

The paper identifies multi-loop activation hubs during macrophage development using Hi-C data, showing they are enriched for AP-1 binding and driven by cell-type specific transcription factors.

The paper assesses exome sequencing in a healthy cohort to determine the frequency of medically actionable and non-actionable findings, finding 17% had actionable variants, including some outside standard guidelines.

On patterned flow cells using exclusion amplification, up to 5-10% of reads are credited to the wrong sample in a pool, traced to free index primers surviving library cleanup.