Wendy W. Y. Choi

This study identifies the ARP2/3 complex as a downstream effector of mTORC1 and mTORC2 hyperactivation in PTEN-deficient neural cells, showing its inhibition can rescue disease phenotypes.

The paper analyzes hypothalamic gene expression in mice across puberty, identifying age- and sex-specific changes and their association with pubertal regulation.

This paper introduces a new targeted sequencing method called Linked Target Capture (LTC) that simplifies and accelerates library preparation while improving on-target read fractions and reducing sequencing costs.

Pro-Seq improves DNA sequencing accuracy without increasing costs by merging DNA copies into single reads, achieving high sensitivity and specificity in liquid biopsies.