Vassilios J. Bezzerides

This study shows that RBFOX2 autoregulation is critical for cardiomyocyte differentiation by maturing the transcriptome, and its disruption leads to congenital heart disease.

This paper introduces REVi-SCOPE, a platform that rapidly characterizes cardiac variants' functional impact, enabling precision cardiology by analyzing VUSs in 10 days.

This study shows that CaMKII phosphorylation of RYR2 at S2814 is essential for arrhythmia in CPVT, acting as an intra-molecular event.

The paper shows that TBX5 recruits CHD4 to regulate chromatin organization in atrial cardiomyocytes, affecting gene expression and atrial rhythm.

This study applies CASAAV-HDR to model cardiomyopathies and perform functional genomics in mouse cardiomyocytes, showing its utility for disease modeling and enhancer analysis.

This paper describes a method to generate high-purity, scalable human iPSC-derived cardiomyocytes using a bioreactor, showing improved viability, function, and consistency compared to traditional methods.