Luciano G. Dolce

This study identifies a direct interaction between the RNA helicase KREH2 and the RESC1-RESC2 complex in trypanosomatid mitochondrial RNA editing using biochemical and structural methods.

The paper reports the cryo-EM structure of METTL6 in complex with SerRS and tRNASer, revealing their interaction and methylation mechanism.

This paper reports cryo-EM structures of the Trypanosoma brucei cap-binding complex (TbCBC) and identifies its interactions with the spliced leader RNA.

The paper reports the cryo-EM structure of the RESC1-RESC2 complex from Trypanosoma brucei, revealing its role in guide RNA selection through 5-triphosphate binding.

This study presents the first structure of a eukaryotic ADAT2/3 deaminase bound to tRNA, revealing sequence-independent substrate selection and a novel gating mechanism for substrate entry.