Ryan David Shepard

AKAP150-anchored PKA regulation of synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the lateral habenula

This study investigates the role of AKAP150 in regulating synaptic transmission, plasticity, and CRF neuromodulation in the lateral habenula using genetic and electrophysiological approaches.

Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors

This study identifies Shisa7 phosphorylation at S405 as critical for GABAAR trafficking and function, leading to altered synaptic inhibition and neurodevelopmental behaviors in mice.

Paradoxical excitation of lateral habenula neurons by propofol involves enhanced presynaptic release of glutamate

This study identifies how propofol excites lateral habenula neurons by enhancing presynaptic glutamate release, promoting sedation through increased synaptic excitation.

Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats

This study shows that early life stress increases glutamatergic synaptic activity in the lateral habenula, which persists into adulthood and reduces morphine intake and reward behavior in rats.

Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

This study shows that early life stress alters kappa opioid receptor signaling in the lateral habenula, affecting neuronal excitability and synaptic transmission in rat models.