David Castellano

This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.

This study shows that co-culturing human iPSC-derived sensory neurons with rodent satellite glia enhances their differentiation and maturation, leading to more mature phenotypes and improved disease modeling.

This study investigates how Shisa7 modulates GABAAR single-channel gating kinetics through single-channel recordings and kinetic analysis, revealing its role in reducing open probability and burst duration.

This study identifies Shisa7 phosphorylation at S405 as critical for GABAAR trafficking and function, leading to altered synaptic inhibition and neurodevelopmental behaviors in mice.

This study identifies distinct roles of GluN2A- and GluN2B-containing NMDA receptors in regulating tonic GABAergic inhibition in hippocampal neurons under physiological and pathological conditions.