Nalini R. Rao

This study identifies DNAJC7 as a mediator of neuroprotection in ALS by modulating HSF1 activity and shows that HSF1 expression can rescue proteotoxic stress in mutant DNAJC7 neurons.

The paper discovers that levetiracetam prevents Aβ42 production by modulating synaptic vesicle cycling, altering APP localization, and favoring non-amyloidogenic processing in Alzheimer's disease models.

The paper isolates and analyzes amyloid fibrils from AD brains and models to identify proteins associated with fibril formation and toxicity, finding new proteins and validating their roles.

This study shows levetiracetam normalizes presynaptic endocytosis proteins and reduces Aβ42 levels in App knock-in mice by altering APP processing.