Mary E. B. McCulloch

Severe perinatal hydrops fetalis in genome edited pigs with a biallelic five base pair deletion of the Marfan syndrome gene, FBN1

This paper reports unexpected severe hydrops fetalis in CRISPR-Cas9 edited pigs with a FBN1 deletion, highlighting potential off-target effects and the need for comprehensive genomic analysis.

Elimination of reference mapping bias reveals robust immune related allele-specific expression in cross-bred sheep

This study develops an unbiased pipeline for allele-specific expression analysis in sheep, revealing pervasive and tissue-specific allelic imbalance across genes and SNVs.

A mini-atlas of gene expression for the domestic goat (Capra hircus) reveals transcriptional differences in immune signatures between sheep and goats

The paper creates a gene expression atlas for goats, identifying transcriptional differences in immune signatures compared to sheep.

Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression

This study characterizes gene expression changes in the gastrointestinal tract of sheep from birth to adulthood, identifying developmental stage-specific differences, particularly in the rumen complex and immune-related genes.

Assembly and validation of conserved long non-coding RNAs in the ruminant transcriptome

The paper identifies a consensus set of ruminant lncRNAs by combining cross-species RNA-seq data and positional conservation, showing that stochastic sampling can be mitigated through this approach.

A High Resolution Atlas Of Gene Expression In The Domestic Sheep (Ovis aries)

This paper presents a high-resolution gene expression atlas for sheep, identifying transcriptional signatures and functional annotations across tissues and developmental stages.