Mark R. Ibberson

This study shows that insulin/IGF1 signaling in podocytes regulates gene transcription by affecting spliceosome function and protein modifications.

This study shows that de novo ceramide synthesis in beta-cells is essential for normal insulin production and glucose tolerance, as its inhibition leads to reduced beta-cell mass and impaired glucose regulation.

This study identifies transcriptomic changes in islet amyloidosis using RNA sequencing and finds a gene co-expression module linked to the condition.

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.

dsSwissKnife enables federated data analysis in R, supporting biomarker discovery across harmonized datasets from multiple observational cohorts.

MetaNetX/MNXref provides a unified namespace for metabolites and reactions, improving reconciliation between biochemistry databases and GSMNs with enhanced mapping tools.