Laura E. Niklason

This study identifies VEGF-D as a key factor in maintaining lung vascular integrity during acute lung injury using single-cell RNA sequencing and functional assays.

This study develops an engineered whole-lung tissue model to study tissue organization and alveolar barrier function, showing improved barrier function with alveolar macrophages.

The paper identifies cell-to-cell communication between mesothelial cells and alveolar tuft cells that regulates lung regeneration after pneumonectomy.

This study uses multi-omic data to identify age-related changes in lung cell composition and molecular programs associated with aging and senescence.

The paper analyzes single-cell RNA sequencing data from early SARS-CoV-2 infection in a humanized model to show how the virus exploits tissue repair mechanisms in airway epithelial cells.

NICHES visualizes cell-cell interactions at the single-cell level using ligand-receptor signaling proxies, enabling analysis of heterogeneous signaling across cell clusters and spatial contexts.

Connectome quantifies and visualizes cell-cell signaling networks from single-cell RNA-sequencing data using a software package for R.