Targeted intragenic demethylation initiates chromatin rewiring for gene activation
Yanjing V. Liu, Mahmoud Adel Bassal, Migara Kavishka Jayasinghe, Quy Xiao Xuan Lin, Chan-Shuo Wu, Jing Ping Tang, Junsu Kwon, Qiling Zhou, Hong Kee Tan, Alexander K. Ebralidze, Minh T. N. Le, Li Chai, Touati Benoukraf, Annalisa Di Ruscio, Daniel Geoffrey Tenen
CRISPR-DiR induces locus-specific demethylation and chromatin remodeling to reactivate the p16 gene.
bioRxiv · Jul 16, 2020 · PreprintGenetics