Kevin Pérez

Photographic age gap is associated with frailty and predicts survival in laboratory mice

This paper uses photographs of mice to predict biological age and finds that older appearance correlates with frailty and shorter survival.

Comprehensive evaluation of lifespan-extending molecules in C. elegans

This study evaluates 16 lifespan-extending molecules in C. elegans, confirming some effects, identifying synergies, and finding conserved effects in Drosophila.

ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age

The paper compares DNA methylation age in four premature aging mouse models, finding ERCC1 mice show the most significant increase in epigenetic age.

In vivo reprogramming leads to premature death due to hepatic and intestinal failure.

This study shows that continuous in vivo reprogramming with OSKM causes hepatic and intestinal failure, leading to premature death, but a new mouse strain reduces these effects.

Development of a novel aging clock based on chromatin accessibility

This paper develops an aging clock using chromatin accessibility data from PBMCs and shows it correlates with transcriptional changes during aging.

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington's Disease and Possible Therapeutic Avenues

The paper uses single-cell RNA sequencing to study Huntington's disease by analyzing medium spiny neuron development in HD iPSC models and identifies potential therapeutic molecules.