Pierre‐François Lenne

The paper develops a pipeline for deep imaging and analysis of multi-layered organoids, revealing gene expression patterns and nuclear morphology in gastruloids.

This paper accelerates fluorescence lifetime imaging (FLIM) using single-objective light-sheet microscopy, achieving faster and less phototoxic imaging of live multicellular systems.

The paper shows how the epithelial-mesenchymal boundary directs cell shape alignment and axis elongation in Xenopus animal cap explants without external cues.

The paper studies Wnt ligand dynamics in C. elegans embryos to show how diffusion enables long-range signaling and cell polarity.

This study shows that mechanical tension drives multi-scale self-organisation in human iPSC-derived muscle fibers by coordinating sarcomere assembly and myofiber bundling.

This study shows how cell-state transitions and collective movement create an endoderm-like region in mouse gastruloids without requiring epithelial-to-mesenchymal transition.

The paper shows that morphogenetic waves in Drosophila endoderm are initiated by transcriptional activation and driven by mechanical feedback, not by continuous gene expression.

The paper visualizes calcium dynamics during Drosophila embryogenesis and identifies calcium transients and waves in specific tissues.

The paper shows that dissipation stabilizes cell shape changes during tissue morphogenesis by analyzing Myosin II activity in Drosophila embryos.