Jennifer F. Kugel

This study identifies CDK7-dependent mechanisms regulating RNAPII function at gene 5'- and 3'-ends through biochemical reconstitution and multi-omics analysis.

The paper uses single-molecule microscopy to show TFIIE subunits dynamically interact with preinitiation complexes, with kinetic changes influenced by TFIIH and disease mutations.

This study shows that HSV-1 protein ICP4 both activates and represses host gene transcription by modulating RNA polymerase II occupancy and promoter pausing.

This study shows miR-206 is critical for myogenesis and identifies new mRNA targets regulated by miR-206 in C2C12 cells.