Cindy R. Sandoval Espinoza

This paper develops GELYTACs, lysosome-targeting chimeras that deplete IgG in vivo via AAV delivery, showing sustained antibody depletion in mice.

The paper investigates DNA repair in postmitotic neurons and shows that manipulating repair pathways can influence CRISPR editing outcomes.

The paper demonstrates programmable enveloped delivery vehicles (EDVs) that enable cell-specific genome editing in vivo and ex vivo by targeting CRISPR-Cas9 to specific cell types.