Jennifer R. Hamilton

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells

This paper develops a virus-like particle-based system for CRISPR gene editing and screening in primary human myeloid cells, identifying TNFAIP3 as a key regulator of inflammatory polarization.

Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes

The paper investigates DNA repair in postmitotic neurons and shows that manipulating repair pathways can influence CRISPR editing outcomes.

Distinct gene programs underpinning 'disease tolerance' and 'resistance' in influenza virus infection

The paper identifies two distinct gene programs associated with disease tolerance and resistance in influenza virus infection using mouse strain data.

Programmable enveloped delivery vehicles for human genome engineering in vivo

The paper demonstrates programmable enveloped delivery vehicles (EDVs) that enable cell-specific genome editing in vivo and ex vivo by targeting CRISPR-Cas9 to specific cell types.