Author

Spencer D. Barnes

The University of Texas Southwestern Medical CenterORCID 0000-0003-1103-0953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Ariella B. HankeriD· 1 shared Atreyi MukherjiiD· 1 shared Carla R. TiradoiD· 1 shared Carlos L. ArteagaiD· 1 shared Choushi WangiD· 1 shared Didem Ağaç ÇobanoğluiD· 1 shared Felix Yi-Chung FengiD· 1 shared Ganesh V. RajiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Ariella B. HankerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cancer BiologyCancer DiscoveryPeer-reviewedApr 8, 2024

ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

Yaru Xu, Yuqiu Yang, Zhaoning Wang…·Ping Mu

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

50 citationstop 2%

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsBioinformaticsPeer-reviewedMay 8, 2019

Accurate differential analysis of transcription factor activity from gene expression

Viren R. Amin, Didem Ağaç Çobanoğlu, Spencer D. Barnes, Murat Can Çobanoğlu

EPEE improves TF activity inference by integrating regulatory networks and accounting for shared targets, showing accuracy in immune and cancer contexts.

4 citations

bulk RNA-seqstatistical model

𝕏 PostBluesky