Author
University of California San DiegoORCID 0000-0002-0290-4746Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Jay Hou, Mariah M. McMahon, Andrew Ni, Zhaoning Wang, Brett Taylor, Timothy H. Loe, Yang Xie, Lei Chang, Andrew M. Gardeck, Ziya Gokaslan, SHIRA I. DUNSIGER, Bing Ren, Clark Chen, David J. Odde
This study identifies two migratory phenotypes in glioblastoma cells ex vivo, linking them to clinical recurrence and tumor heterogeneity.
bioRxiv · Sep 2, 2026 · PreprintCancer Biology
Zhaoning Wang, Songpeng Zu, Ethan J. Armand, Timothy H. Loe, Jonathan A. Rink, Wanying Wu, Yang Xie, Lei Chang, Chenxu Zhu, Nicholas D. Johnson, Jasper Lee, Jackson K. Willier, Silvia Cho, Stella Maris Cao, Ariana S. Barcoma, , Bing Ren
The paper constructs an integrative single-cell epigenomic atlas of the adult mouse brain, mapping chromatin states and gene regulatory programs across 100 cell subclasses.
bioRxiv · Jul 21, 2026 · PreprintGenomics
Brett Taylor, Weixiu Dong, Tula Ann Keal, Zhaoning Wang, Bharath Saravanan, Zane A. Gibbs, Yohei Miyake, Daisuke Kawauchi, Raghavendra Vadla, Abhinaba Banerjee, Omar M. Elkassih, Sahana Kashyap, B. Jones, Kseniya Malukhina, Mahsa Nafisi, , Bogdan Bintu
This study uses single-molecule spatial genomics to show how extrachromosomal DNA is organized and regulated in glioblastoma, linking it to tumor heterogeneity and microenvironmental influences.
bioRxiv · Mar 7, 2026 · PreprintGenomics
Lei Chang, Kai Li, Yang Xie, Guojie Zhong, Jonathan A. Rink, Cindy Tatiana Báez-Becerra, Anita Lie, Hannah S. Indralingam, Keyi Dong, Timothy H. Loe, Zhaoning Wang, Songpeng Zu, Joseph Colin Kern, Zoey Zhao, Eric Boone, , Bing Ren
This paper presents a single-cell multiome atlas of the human basal ganglia, linking chromatin states and transcriptomes to cell-type identity and disease-associated variants.
bioRxiv · Feb 4, 2026 · PreprintGenomics
Yang Xie, Lei Chang, Guojie Zhong, Jonathan A. Rink, Tatiana Baez-Becerra, Ethan J. Armand, Wubin Ding, Kai Li, Éric Bonne, Anita Lie, Hannah S. Indralingam, Keyi Dong, Timothy H. Loe, Bohan Huang, Zhaoning Wang, , Bing Ren
The paper creates a single-cell atlas of transcription and chromatin states in the human brain, identifying regulatory programs and linking them to neuropsychiatric disorders.
bioRxiv · Feb 3, 2026 · PreprintGenomics
Yang Xie, Luca Tucciarone, Elie N. Farah, Lei Chang, Qian Yang, Thirupura Sundari Shankar, Weston S. Elison, Shaina Tran, Jovina Djulamsah, Anita Lie, Timothy H. Loe, Alyssa R. Holman, Sierra Corban, Justin Buchanan, Sainath Mamde, , C. Neil
The paper integrates single-cell multi-omics and 3D genome data from human hearts to identify gene regulatory changes and causal genetic contributors in heart failure.
medRxiv · May 8, 2025 · PreprintGenetic & Genomic Medicine
Lei Chang, Yang Xie, Brett Taylor, Zhaoning Wang, Jiachen Sun, Tuyet M. Tan, Rafael L. Bejar, Clark C. Chen, Frank B. Furnari, Ming Hu, Bing Ren
The paper introduces Droplet Hi-C, a method for single-cell chromatin conformation profiling, and demonstrates its application in analyzing gene regulatory programs and detecting genetic variations in cancer cells.
bioRxiv · Apr 18, 2024 · PreprintGenomics
Yang Eric Li, Sebastian Preißl, Michael Miller, Nicholas D. Johnson, Zihan Wang, Henry Jiao, Chenxu Zhu, Zhaoning Wang, Yang Xie, Olivier Poirion, Colin Kern, António Pinto‐Duarte, Wei Tian, Kimberly Siletti, Nora Emerson, , Bing Ren
The paper constructs a single-cell chromatin accessibility atlas of the human brain, identifies cell-type-specific regulatory elements, and develops models to predict regulatory function of disease risk variants.
Science · Oct 12, 2023Peer-reviewedNeuroscience