Author
Moffitt Cancer CenterORCID 0000-0003-1133-5554Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Xiaonan Xu, Vinesh Jarajapu, Manon Chadourne…·Florian A. Karreth
This study identifies FRA1 as a driver of melanoma metastasis and shows that targeting its downstream genes AXL, CDK6, and FSCN1 suppresses metastasis and improves survival.
Manon Chadourne, Crystal Griffith, Neel Jasani…·Florian A. Karreth
Xiaonan Xu, Xiaoxian Liu, James Jarad Dollar…·Florian A. Karreth
This paper develops a genetically engineered mouse model of uveal melanoma that recapitulates human disease progression and immune microenvironment features, revealing phenotypic plasticity and cooperative genetic drivers.
Neel Jasani, Xiaonan Xu, Benjamin Posorske…·Florian A. Karreth
This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.