Steven Lisgo

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

This paper creates a multi-omics atlas of human hindbrain development, revealing cellular diversity, regulatory programs, and disease relevance.

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

The paper presents a spatial transcriptomic atlas of autism-associated genes in the developing human brain, identifying convergence in the thalamus and germinal zones.

The paper identifies a novel epithelial population, Zippering Lambda, whose cell cycle arrest is critical for facial prominence fusion and is disrupted in orofacial clefting.

The paper identifies transcriptional changes in the avian brain during visual imprinting using single-nucleus RNA sequencing, revealing cell clusters and lncRNAs linked to memory formation.

This study analyzes gene regulatory programs in primate gonads, finding shared and species-specific regulatory dynamics and candidate genes for sex development disorders.

The paper identifies extracellular components in the developing fetal neocortex of humans and non-human primates using multi-omics approaches.

This study uses spatial transcriptomics to analyze human embryonic arterial valves, identifying novel genes and pathways involved in valve development and highlighting limitations in current genomic databases.

This study creates a prenatal human skin cell atlas, revealing immune cells' role in skin development and showing their impact on vascular and hair follicle formation.

The paper identifies 14,000 human craniofacial enhancers across developmental stages and shows 56% are conserved in mice, providing cell type- and stage-specific activity profiles.

This paper introduces a 3D in vitro model of human somitogenesis using pluripotent stem cells, showing accurate segmentation dynamics and disease relevance.

The paper identifies widespread epigenomic changes in idiopathic dilated cardiomyopathy, showing a shift toward fetal-like enhancer states and providing a data resource for further study.

The paper maps the multi-organ functions of the human yolk sac during early development, revealing its roles in hematopoiesis, nutrition, and oxygen regulation.

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

This study maps the spatial and single-cell transcriptional landscape of human cerebellar development, revealing cell-type-specific gene expression and implications for neurological disorders.

This paper generates a single-cell atlas of the human cornea across development and disease, identifying key cell types, markers, and interactions that inform stem cell maintenance and disease mechanisms.

The paper identifies widespread and defined expression patterns of CEP164 in human embryonic and foetal tissues, with similar patterns observed in mice, suggesting conserved developmental roles contributing to multi-system disease.

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.

Spaniel is an R package for analyzing and sharing spatial transcriptomics data, addressing challenges in existing tools.

The paper profiles single-cell transcriptomes from the human first trimester fetal-maternal interface, revealing cellular composition and interactions critical for placentation.

The paper examines gene expression asymmetry in human embryos and fetuses, finding structure-specific transcriptomic laterality that correlates with age-related changes but not consistent left-right orientation.