Pei‐Hsuan Wu

Molecular factors shaping small RNA content in mouse sperm

This study identifies molecular factors shaping small RNA content in mouse sperm, revealing dynamics and protein associations during spermiogenesis and capacitation.

The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila

This study shows that reducing NMN levels in Drosophila prevents axon degeneration and neurodegeneration, revealing NMN's role in axon injury and disease.

Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons

This study shows PIWI-clade Argonaute proteins can cleave transposon transcripts with mismatches, making them more effective against mutating transposons than AGO-clade Argonautes.

An Evolutionarily Conserved piRNA-producing Locus Required for Male Mouse Fertility

This study identifies a conserved piRNA locus, pi6, essential for male mouse fertility and embryo viability by regulating sperm function through mRNA cleavage.

Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers

The paper develops methods to eliminate PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers, showing improved data reproducibility and reduced bias.