Stem cell control and cancer initiation by an autocrine, injury-activated Igf complex
Yue Zhang, Youcef Ouadah, Yin Liu, Maya E. Kumar, Makenna M. Morck, Mark A. Krasnow
The paper identifies Igf2 as an injury-activated mitogen for neuroendocrine stem cells and shows its role in cancer initiation through receptor activation and Rb repression.
bioRxiv · Apr 2, 2026 · PreprintCell Biology