Yue Zhang

Stem cell control and cancer initiation by an autocrine, injury-activated Igf complex

The paper identifies Igf2 as an injury-activated mitogen for neuroendocrine stem cells and shows its role in cancer initiation through receptor activation and Rb repression.

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

Tabula Microcebus: A transcriptomic cell atlas of mouse lemur, an emerging primate model organism

The paper creates a comprehensive cell atlas of mouse lemurs using single-cell RNA sequencing, identifying over 750 cell types and comparing their molecular profiles to humans, mice, and macaques.

Direct induction of human neurons from fibroblasts carrying the neuropsychiatric 22q11.2 microdeletion reveals transcriptome- and epigenome-wide alterations

This paper develops a method to generate neuronal cells from adult fibroblasts and uses it to study gene expression and epigenetic changes in 22q11.2 deletion syndrome.

Dach1 extends artery networks and protects against cardiac injury

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.