Cansu Colpan

This study shows PIWI-clade Argonaute proteins can cleave transposon transcripts with mismatches, making them more effective against mutating transposons than AGO-clade Argonautes.

This study shows that terminal modifications like 2'-O-methylation and trimming protect piRNAs from decay, while complementarity affects miRNA stability in mice and flies.

The paper shows that A-MYB activates TCFL5, which is essential for meiosis and spermiogenesis in placental mammals, and its loss causes sterility.

This study identifies a conserved piRNA locus, pi6, essential for male mouse fertility and embryo viability by regulating sperm function through mRNA cleavage.

The paper shows Maelstrom represses canonical transcription in piRNA clusters, enabling Rhi to initiate piRNA precursor transcription.

The paper proposes a unified mechanism for piRNA biogenesis initiated by PIWI proteins, showing it operates across diverse animal species.