Joel Vega‐Badillo

The paper identifies and characterizes miRNA binding sites in Drosophila using RNA Bind-n-Seq, revealing differences in binding site diversity and affinity compared to mammals.

This study shows PIWI-clade Argonaute proteins can cleave transposon transcripts with mismatches, making them more effective against mutating transposons than AGO-clade Argonautes.

This study shows that terminal modifications like 2'-O-methylation and trimming protect piRNAs from decay, while complementarity affects miRNA stability in mice and flies.

This paper demonstrates that circular ssDNA donors improve HDR efficiency and reduce off-target integration compared to linear ssDNA donors in mammalian cells.