Nicolas V. Janto

This study shows Tet1 buffers intestinal stem cell differentiation by reducing sensitivity to extrinsic signals, without altering chromatin accessibility.

This study shows that Tritrichomonas muris increases doxorubicin-induced intestinal apoptosis in mice without altering tissue morphology, and reduces intestinal stem cell gene expression post-injury.

This study shows that Lgr5+ intestinal stem cells are necessary for organoid survival after genotoxic injury, despite fISC gene activation occurring at both low and high doses of doxorubicin.

This study identifies Rad52, Rad59, Srs2, and the MRX complex as essential for Rad51-independent single-strand template repair in yeast, showing distinct genetic requirements compared to Rad51-dependent repair.