Siyang Sun

This study shows Tet1 buffers intestinal stem cell differentiation by reducing sensitivity to extrinsic signals, without altering chromatin accessibility.

This study shows that Tritrichomonas muris increases doxorubicin-induced intestinal apoptosis in mice without altering tissue morphology, and reduces intestinal stem cell gene expression post-injury.

This study shows that Lgr5+ intestinal stem cells are necessary for organoid survival after genotoxic injury, despite fISC gene activation occurring at both low and high doses of doxorubicin.