Antoine R. Gleizes

Tet1 safeguards lineage allocation in intestinal stem cells

This study shows Tet1 buffers intestinal stem cell differentiation by reducing sensitivity to extrinsic signals, without altering chromatin accessibility.

Tritrichomonas muris sensitizes the intestinal epithelium to doxorubicin-induced apoptosis

This study shows that Tritrichomonas muris increases doxorubicin-induced intestinal apoptosis in mice without altering tissue morphology, and reduces intestinal stem cell gene expression post-injury.

Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury

This study shows that Lgr5+ intestinal stem cells are necessary for organoid survival after genotoxic injury, despite fISC gene activation occurring at both low and high doses of doxorubicin.