BiochemistryMatrix BiologyPeer-reviewed
Heparan sulfate selectively inhibits the collagenase activity of cathepsin K
Xiaoxiao Zhang, Yin Luo, Huanmeng Hao…·Ding Xu
This study shows heparan sulfate inhibits cathepsin K collagenase activity while preserving peptidase activity, revealing HS as a potential therapeutic target for bone resorption diseases.