Jian Liu

This study identifies an RBP-J-HS-dependent network that regulates macrophage fate between inflammation and osteoclastogenesis in response to TNF.

This study shows heparan sulfate inhibits MMP13 collagenase activity but not non-collagen substrate degradation, revealing HS as a regulator of MMP13 through exosite binding.

The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.

This paper introduces HS-nano-seq, a method to analyze heparan sulfate using nanopore sequencing, enabling single-molecule detection of sulfation patterns and structural features.

This study shows heparan sulfate promotes pro-CtsK autoprocessing by disrupting an electrostatic interaction between the propeptide and catalytic domain.

This study shows heparan sulfate inhibits cathepsin K collagenase activity while preserving peptidase activity, revealing HS as a potential therapeutic target for bone resorption diseases.