Heparan sulfate selectively inhibits the collagenase activity of matrix metalloproteinase 13
Huanmeng Hao, Guowei Su, Jian Liu, Ding Xu
This study shows heparan sulfate inhibits MMP13 collagenase activity but not non-collagen substrate degradation, revealing HS as a regulator of MMP13 through exosite binding.