Lea Sistonen

This study shows that dynamic regulation of HSF2 drives breast cancer progression by balancing proliferation and invasion through TGF-β signaling.

This study shows HSF2 promotes gamma-herpesvirus lytic gene expression by altering chromatin structure at key viral promoters.

This study identifies a nuclear subpopulation of Talin 1 that regulates gene expression in human breast epithelial cells.

The paper tracks transcription during erythroid differentiation and identifies NRF2's role in initiating an antioxidant program without oxidative stress.

The paper shows that CBP/EP300 acetylates and stabilizes HSF2, which is disrupted in Rubinstein-Taybi syndrome, leading to impaired heat shock response.

The paper provides analytical steps to identify regulatory elements and quantify transcription complexes using nascent RNA-sequencing data in human cells.

This study shows HSF1 and HSF2 regulate gene and enhancer transcription differently under oxidative stress and heat shock by controlling RNA polymerase II pause-release.

This study shows that heat shock induces transcriptional memory in cells, accelerating promoter-proximal pause-release and slowing termination over mitotic divisions.