Samu V. Himanen

The paper characterizes transcriptional architectures and Pol II regulation in dog cells, revealing promoter, enhancer, and enhancer cluster structures and their response to heat stress.

The paper tracks transcription during erythroid differentiation and identifies NRF2's role in initiating an antioxidant program without oxidative stress.

This study uses PRO-seq to profile nascent transcription in Aedes aegypti, identifying regulatory elements and dynamic immune responses to bacterial stimulation.

The paper introduces PRO-IP-seq to track Pol II CTD phosphorylation at nucleotide resolution and reveals its dynamic regulation during transcription.

This study shows HSF1 and HSF2 regulate gene and enhancer transcription differently under oxidative stress and heat shock by controlling RNA polymerase II pause-release.

This study shows that heat shock induces transcriptional memory in cells, accelerating promoter-proximal pause-release and slowing termination over mitotic divisions.