Author

Mikael Christer Puustinen

Åbo Akademi UniversityORCID 0000-0002-1253-8532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lea SistoneniD· 4 shared Alejandro J. Da SilvaiD· 3 shared Anniina VihervaaraiD· 2 shared Hendrik S. E. HästbackaiD· 2 shared Jenny C. PessaiD· 2 shared Agathe Duchateau· 1 shared Alain VerloèsiD· 1 shared Anna L. AaltoiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMolecular Biology

Lea SistonenORCID

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4 papers

Recent·Most cited

Dynamic HSF2 regulation drives breast cancer progression by steering the balance between proliferation and invasion

Jenny C. Pessa, Oona Paavolainen, Mikael Christer Puustinen, Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Sandra Pihlström, Silvia Gramolelli, Pia Boström, Pauliina Hartiala, Emilia Peuhu, Jenny Joutsen, Lea Sistonen

This study shows that dynamic regulation of HSF2 drives breast cancer progression by balancing proliferation and invasion through TGF-β signaling.

Science Advances · Sep 3, 2025Peer-reviewedCell Biology

A subpopulation of Talin 1 resides in the nucleus and regulates gene expression

Alejandro J. Da Silva, Hendrik S. E. Hästbacka, Mikael Christer Puustinen, Jenny C. Pessa, Jens C. Luoto, Erika Sundström, Benjamin Thomas Goult, Guillaume Jacquemet, Eva Henriksson, Lea Sistonen

This study identifies a nuclear subpopulation of Talin 1 that regulates gene expression in human breast epithelial cells.

iScience · Jan 5, 2025Peer-reviewedMolecular Biology

CBP/EP300 acetylates and stabilizes the stress-responsive Heat Shock Factor 2, a process compromised in Rubinstein-Taybi syndrome

Aurélie de Thonel, Johanna K. Ahlskog, Kévin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón-Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, , Valérie Mezger

The paper shows that CBP/EP300 acetylates and stabilizes HSF2, which is disrupted in Rubinstein-Taybi syndrome, leading to impaired heat shock response.

Nature Communications · Nov 16, 2022Peer-reviewedDevelopmental Biology

HSFs drive stress type-specific transcription of genes and enhancers

Samu V. Himanen, Mikael Christer Puustinen, Alejandro J. Da Silva, Anniina Vihervaara, Lea Sistonen

This study shows HSF1 and HSF2 regulate gene and enhancer transcription differently under oxidative stress and heat shock by controlling RNA polymerase II pause-release.

bioRxiv · Nov 23, 2021 · PreprintMolecular Biology