Raymond A. Swanson

This study evaluates hexokinase-2 inhibitors' effects on post-stroke inflammation and neuroprotection, finding that selective inhibitors reduce microglial activation and improve functional outcomes.

This study investigates the role of PATJ in cell stress responses and vascular remodeling after stroke using a mouse model and CRISPR-Cas9 knockout cells.

This study shows that post-stroke hyperglycemia worsens brain injury by increasing oxidative stress and impairing motor recovery in mice.

This study identifies cofilin dysregulation as a mediator of α-synuclein-induced synaptic dysfunction in hippocampal neurons in synucleinopathy models.

This study shows superoxide enters neurons directly through LRRC8A-containing volume-regulated anion channels, blocking oxidative stress and glutamate excitotoxicity.

This study shows that α-synuclein aggregates cause c-Abl activation via redox stress, leading to neurodegeneration, and that N-acetyl cysteine can block this process in Parkinson's disease models.

This study examines cofilin-actin rod formation in different mouse models of brain ischemia and finds that rod formation varies with ischemic conditions and reperfusion timing.