Shuai Ni

CESAR improves CNV detection in low-tumor fraction ctDNA by recalibrating depth ratios using anchor selection and segmentation, outperforming CNVkit in sensitivity and reproducibility.

TargetSureR assesses siRNA off-target risks using a seven-dimensional scoring system and enables cross-species model selection for preclinical safety evaluation.

LISA is an R package for analyzing lentiviral integration sites in gene therapy to assess safety by identifying risk-associated genomic regions and tracking clonal dynamics.

The paper investigates how RNA-binding proteins (RBPs) change in response to viral infection and identifies RBPs crucial for viral replication.